AI agent selects epilepsy therapy and performs mouse brain surgery under human safety gates

An AI agent autonomously selected a gene therapy vector, brain target and injection coordinates, then executed brain surgery on an epileptic mouse, according to the author. It delivered 250 nanolitres (5e8 viral genomes) into the lateral entorhinal cortex at coordinates derived from three papers. A licensed vet held a physical kill switch and gated irreversible steps. The agent refused to proceed during a calibration fault it correctly detected. Anthropic's Opus 5.5 refused bio tasks and Opus 5 declined live surgery; Sonnet 5 completed it. The mouse recovered.

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